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Indole
・ Indole 2,3-dioxygenase
・ Indole alkaloid
・ Indole test
・ Indole-2-monooxygenase
・ Indole-3-acetaldehyde oxidase
・ Indole-3-acetaldehyde reductase (NADH)
・ Indole-3-acetaldehyde reductase (NADPH)
・ Indole-3-acetate beta-glucosyltransferase
・ Indole-3-acetic acid
・ Indole-3-butyric acid
・ Indole-3-carbinol
・ Indole-3-carboxylate decarboxylase
・ Indole-3-glycerol-phosphate lyase
・ Indole-3-glycerol-phosphate synthase


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Indole : ウィキペディア英語版
Indole

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Indole is an aromatic heterocyclic organic compound. It has a bicyclic structure, consisting of a six-membered benzene ring fused to a five-membered nitrogen-containing pyrrole ring. Indole is widely distributed in the natural environment and can be produced by a variety of bacteria. As an intercellular signal molecule, indole regulates various aspects of bacterial physiology, including spore formation, plasmid stability, resistance to drugs, biofilm formation, and virulence. The amino acid tryptophan is an indole derivative and the precursor of the neurotransmitter serotonin.〔
== General properties and occurrence ==
Indole is a solid at room temperature. Indole can be produced by bacteria as a degradation product of the amino acid tryptophan. It occurs naturally in human feces and has an intense fecal odor. At very low concentrations, however, it has a flowery smell,〔http://www.leffingwell.com/olfact5.htm〕 and is a constituent of many flower scents (such as orange blossoms) and perfumes. It also occurs in coal tar.
The corresponding substituent is called indolyl.
Indole undergoes electrophilic substitution, mainly at position 3. Substituted indoles are structural elements of (and for some compounds the synthetic precursors for) the tryptophan-derived tryptamine alkaloids like the neurotransmitter serotonin, and melatonin.
Other indolic compounds include the plant hormone auxin (indolyl-3-acetic acid, IAA), tryptophol, the anti-inflammatory drug indomethacin, the betablocker pindolol, and the naturally occurring hallucinogen dimethyltryptamine.
The name ''indole'' is a portmanteau of the words ''indigo'' and ''oleum'', since indole was first isolated by treatment of the indigo dye with oleum.

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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