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Hypoxia-inducible factors (HIFs) are transcription factors that respond to changes in available oxygen in the cellular environment, to be specific, to ''decreases'' in oxygen, or hypoxia. == Structure == Most, if not all, oxygen-breathing species express the highly-conserved transcriptional complex HIF-1, which is a heterodimer composed of an alpha and a beta subunit, the latter being a constitutively-expressed aryl hydrocarbon receptor nuclear translocator (ARNT). HIF-1 belongs to the PER-ARNT-SIM (PAS) subfamily of the basic helix-loop-helix (bHLH) family of transcription factors. The alpha and beta subunit are similar in structure and both contain the following domains: * N-terminus – a bHLH domain for DNA binding * central region – Per-ARNT-Sim (PAS) domain, which facilitates heterodimerization * C-terminus – recruits transcriptional coregulatory proteins 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Hypoxia-inducible factors」の詳細全文を読む スポンサード リンク
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