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HDMP-28 or methylnaphthidate is a piperidine based stimulant drug, closely related to methylphenidate, but with the benzene ring replaced by naphthalene. It is a potent dopamine reuptake inhibitor, with several times the potency of methylphenidate and a short duration of action,〔Lile JA, Wang Z, Woolverton WL, France JE, Gregg TC, Davies HM, Nader MA. The reinforcing efficacy of psychostimulants in rhesus monkeys: the role of pharmacokinetics and pharmacodynamics. ''Journal of Pharmacology and Experimental Therapeutics''. 2003 Oct;307(1):356-66. PMID 12954808〕 and is a structural isomer of another potent dopamine reuptake inhibitor, N,O-Dimethyl-4-(2-naphthyl)piperidine-3-carboxylate. 200px Most of the TMP analogs of HDMP-28 have SERT Ki values in the range >10,000 and so are selective for dopamine and noradrenaline reuptake, with little or no effect on serotonin. HDMP-28 also has high affinity to SERT, and so behaves as a triple reuptake inhibitor.〔Davies HM, Hopper DW, Hansen T, Liu Q, Childers SR. Synthesis of methylphenidate analogues and their binding affinities at dopamine and serotonin transport sites. Bioorg Med Chem Lett. 2004 Apr 5;14(7):1799-802. PMID 15026075〕 D.R. = Discrimination Ratio = ()DA ÷ ()CFT. A low D.R. = addictive, whereas a high D.R. = low propensity for self-administration. == See also == * 3,4-Dichloromethylphenidate * Ethylphenidate * HDEP-28 * Naphthylisopropylamine * Naphyrone * 2β-Propanoyl-3β-(2-naphthyl)-tropane (WF-23) * Isopropylphenidate * Propylphenidate 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「HDMP-28」の詳細全文を読む スポンサード リンク
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