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・ Grammoptera exigua
・ Grammoptera haematites
・ Grammoptera militaris
・ Grammoptera molybdica
・ Grammoptera rhodopus
・ Grammoptera subargentata
・ Grammoscelis
・ Grammostola
・ Grammostola actaeon
・ Grammostola porteri
・ Grammostola pulchra
・ Grammostola pulchripes
・ Grammothele
・ Grammotheleaceae
・ Grammothelopsis
Grammotoxin
・ Grammow
・ Grammoxyla hieroglyphica
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Grammotoxin : ウィキペディア英語版
Grammotoxin

Grammotoxin is a toxin in the venom of the tarantula ''Grammostola spatulata''. It is a protein toxin that inhibits P-, Q- and N-type voltage-gated calcium channels (Ca 2+ channels) in neurons. Grammotoxin is also known as omega-grammotoxin SIA.
== Chemistry ==

Grammotoxin is a 36 Amino Acid protein toxin, which has the following sequence:
Asp-Cys-Val-Arg-Phe-Trp-Gly-Lys-Cys-Ser-Gln-Thr-Ser-Asp-Cys-Cys-Pro-His-Leu-Ala-Cys-Lys-Ser-Lys-Trp-Pro-Arg-Asn-Ile-Cys-Val-Trp-Asp-Gly-Ser-Val (1)
It forms an inhibitor cystine knot motif, common in spider toxins.〔
Its chemical formula is: C177H268N52O50S6〔(ω-Grammotoxin SIA from Grammostola spatulata venom, ≥98% (HPLC) )〕
Grammotoxin can be purified from ''Grammostola spatulata'' venom by reverse phase high performance liquid chromatography.

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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