翻訳と辞書 Words near each other ・ Glycoprotein 3-alpha-L-fucosyltransferase ・ Glycoprotein 6-alpha-L-fucosyltransferase ・ Glycoprotein endo-alpha-1,2-mannosidase ・ Glycoprotein Ib ・ Glycoprotein Ib-IX-V Receptor Complex ・ Glycoprotein IIb/IIIa ・ Glycoprotein IIb/IIIa inhibitors ・ Glycoprotein IX ・ Glycoprotein N-palmitoyltransferase ・ Glycoprotein O-fatty-acyltransferase ・ Glycoprotein-fucosylgalactoside a-N-acetylgalactosaminyltransferase ・ Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase ・ Glycoproteinosis ・ Glycoproteomics ・ Glycopyrronium bromide ・ Glycorandomization ・ Glycosaminoglycan ・ Glycosaminoglycan galactosyltransferase ・ Glycoside ・ Glycoside hydrolase ・ Glycoside hydrolase family 1 ・ Glycoside hydrolase family 10 ・ Glycoside hydrolase family 100 ・ Glycoside hydrolase family 101 ・ Glycoside hydrolase family 108 ・ Glycoside hydrolase family 11 ・ Glycoside hydrolase family 12 ・ Glycoside hydrolase family 13 ・ Glycoside hydrolase family 14 ・ Glycoside hydrolase family 15 Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Glycorandomization ： ウィキペディア英語版 Glycorandomization Glycorandomization, is a drug discovery and drug development technology platform to enable the rapid diversification of bioactive small molecules, drug leads and/or approved drugs through the attachment of sugars. Initially developed as a facile method to manipulate carbohydrate substitutions of naturally-occurring glycosides to afford the corresponding differentially glycosylated natural product libraries, glycorandomization applications have expanded to include both small molecules (drug leads and approved drugs) and even macromolecules (proteins). Also referred to as 'glycodiversification', glycorandomization has led to the discovery of new glycoside analogs which display improvements in potency, selectivity and/or ADMET as compared to the parent molecule. == Classification == The traditional method for attaching sugars to natural products, drugs or drug leads is by chemical glycosylation. This classical approach typically requires multiple protection/deprotection steps in addition to the key anomeric activation/coupling reaction which, depending upon the glycosyl donor/acceptor pair, can lead to a mixture of anomers. Unlike classical chemical glycosylation, glycorandomization methods are divergent (''i.e.'', diverge from a common starting material, see divergent synthesis) and are not dependent upon sugar/aglycon protection/deprotection or sugar anomeric activation. Two complementary strategies to achieve glycorandomization/diversification have been developed: an enzyme-based strategy referred to as 'chemoenzymatic glycorandomization' and a chemoselective method known as 'neoglycorandomization'. Both methods start with free reducing sugars and a target aglycon to afford a library of compounds which differ solely by the sugars appended to the target natural product, drug or drug lead. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Glycorandomization」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.