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gadd7 (growth arrested DNA-damage inducible gene 7) is a non-coding RNA discovered in the ovaries of the chinese hamster (''Cricetulus griseus''). Homologs have been identified in the closely related Long-tailed Dwarf Hamster (''C. longicaudatus''). Although the gene for this RNA contains open reading frames, translation studies found no protein product hence gadd7 has been classified as non-coding RNA.〔 〕 gadd7 was previously characterised as a hydrogen peroxide-inducible transcript〔 but has more recently been linked with lipotoxicity〔 - where the accumulation of lipids in non-adipose tissue brings about cell death. gadd7 appears to be a key element in the lipotoxicty pathway, when it is knocked out the resulting mutant is much more resistant to oxidative stress. The proposed mechanism for gadd7's role in lipotoxicity is:〔 # The lipid palmitate builds to high concentration within a cell # Reactive oxygen species (ROS) are generated # This stress induces the expression of gadd7 # A feed-forward mechanism occurs # ER stress brings about death of the cell ==References== 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Gadd7」の詳細全文を読む スポンサード リンク
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