翻訳と辞書 Words near each other ・ Eidsvoll 1814s ・ Eidsvoll Station ・ Eidsvoll Station (1854–1998) ・ Eidsvoll Ullensaker Blad ・ Eidsvoll Verk ・ Eidsvoll Verk Station ・ Eidsvoll Warranty ・ Eid og Voll ・ EID Parry ・ Eid prayers ・ Eid, Hordaland ・ Eid, Møre og Romsdal ・ Eid, Norway ・ Eid-e-Shuja' ・ EID1 ・ EID2 ・ Eidai SC ・ Eidanger ・ Eidanger Station ・ Eidangerfjord ・ Eidapere ・ Eidberg ・ Eidbukta ・ Eide ・ Eide (disambiguation) ・ Eide (surname) ・ Eide Bailly LLP ・ Eide Church ・ Eide Marine Services ・ Eide, Aust-Agder Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク EID2 ： ウィキペディア英語版 EID2 EP300 interacting inhibitor of differentiation 2, also known as EID2 is a human gene. ==Function== The protein encoded by this gene may function as an endogenous suppressor of TGF-beta signaling and inhibits differentiation by blocking the histone acetyltransferase activity of p300, class I histone deacetylase, HDACs. The N-terminal portion of EID-2 was required for the binding to HDACs. This region was also involved in the transcriptional repression and nuclear localization, suggesting the importance of the involvement of HDACs in the EID-2 function. EID-2 inhibits TGF-beta/Smad transcriptional responses. EID-2 interacts constitutively with Smad proteins, and most strongly with Smad3. Stable expression of EID-2 in the TGF-beta1-responsive cell line inhibits endogenous Smad3-Smad4 complex formation and TGF-beta1-induced expression of p21 and p15. EID-2 displays developmentally regulated expression with high levels in adult heart and brain. Overexpression of EID-2 inhibits muscle-specific gene expression through inhibition of MyoD-dependent transcription. This inhibitory effect on gene expression can be explained by EID-2's ability to associate with and inhibit the acetyltransferase activity of p300. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「EID2」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.