|
Detyrosination is a form of posttranslational modification that occurs on alpha-tubulin. It consists of the removal of the C-terminal tyrosine to expose a glutamate at the newly formed C-terminus. Tubulin polymers, called microtubules, that contain detyrosinated alpha-tubulin are usually referred to as ''Glu-microtubules'' while unmodified polymers are called ''Tyr-microtubules''. Although the tubulin carboxypeptidase has yet to be identified, its activity was first identified in the late 1970s. It is a slow acting enzyme that uses polymeric tubulin as a substrate. As a result, only stabilized microtubules accumulate this particular modification. Tubulin detyrosination is reversed by the tubulin-tyrosine ligase, which acts only on alpha-tubulin monomer. Since the majority of microtubules are very dynamic, they do not contain much detyrosinated tubulin. ==See also== *Polyglutamylation *Polyglycylation *Acetylation 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Detyrosination」の詳細全文を読む スポンサード リンク
|