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|Section2= |Section3= }} Deoxyepinephrine, also known by the common names N-methyldopamine and epinine, is an organic compound and natural product that is structurally related to the important neurotransmitters dopamine and epinephrine. All three of these compounds also belong to the catecholamine family. The pharmacology of epinine largely resembles that of its "parent", dopamine. Epinine has been found in plants, insects and animals. It is also of significance as the active metabolic breakdown product of the prodrug ibopamine, which has been used to treat congestive heart failure.〔P. A. Zwieten (1994). "Pharmacotherapy of congestive heart failure." ''Pharmacy World & Science'' 16 334 - 342.〕〔R. Gifford, W. C. Randolph, F. C. Heineman and J. A. Ziemniak (1986). "Analysis of epinine and its metabolites in man after oral administration of its pro-drug ibopamine using high-performance liquid chromatography with electrochemical detection." ''Journal of Chromatography B'' 381 83-93. doi 10.1016/S0378-4347(00)83567-7〕 ==Occurrence== Epinine does not seem to occur widely, but it is present as a minor alkaloid in some plants, such as the peyote cactus, ''Lophophora williamsii'',〔J. Lundstrom (1971). "Biosynthesis of mescaline and tetrahydroisoquinoline alkaloids in ''Lophophora williamsii'' (Lem.) Coult. Occurrence and biosynthesis of catecholamine and other intermediates." ''Acta Chem. Scand.'' 25 3489-3499. http://actachemscand.dk/pdf/acta_vol_25_p3489-3499.pdf〕 and a species of ''Acacia'',〔B. A. Clement, C. M. Goff and T. D. A. Forbes (1998). "Toxic amines and alkaloids from ''Acacia rigidula''." ''Phytochem.'' 49 1377-1380.〕 as well as in Scotch Broom, ''Cytisus scoparius''.〔T. A. Smith (1977). "Phenethylamine and related compounds in plants." ''Phytochem.'' 16 9-18.〕 This compound has also been isolated from the adrenal medulla of pigs and cows,〔P. Laduron, P. van Gompel, J. Leysen and M. Claeys (1974). " ''In vivo'' formation of epinine in adrenal medulla. A possible step for adrenaline biosynthesis." ''Naunyn-Schmiedebergs Arch. Pharmacol.'' 286 227-238.〕 and from the toad, ''Bufo marinus''.〔F. Märki, J. Axelrod and B. Witkop (1962). "Catecholamines and N-methyltransferase in the South American toad (''Bufo marinus'')." ''Biochim. Biophys. Acta'' 58 367-369.〕 It has also been detected in the locust, ''Locusta migratoria''.〔S. Tanaka and N. Takeda (1997). "Biogenic monoamines in the brain and the corpus cardiacum between albino and normal strains of the migratory locust, ''Locusta migratoria''." ''Comp. Biochem. Physiol. Pt. C: Comp. Pharmacol. Toxicol.'' 117 221-227.〕 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Deoxyepinephrine」の詳細全文を読む スポンサード リンク
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