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DDAIP : ウィキペディア英語版
DDAIP

DDAIP is a pharmaceutical ingredient added to topical products to increase penetration through the skin. Chemically, DDAIP is an ester of ''N'',''N''-dimethylalanine and dodecanol. DDAIP is typically formulated as its hydrochloride salt (DDAIP.HCl). This salt is a white crystalline solid with a melting range of 88-93°C and is an amphiphilic molecule with a pKa of 4.87 that is soluble in water up to about 40% w/v. DDAIP is proprietary to NexMed USA, a subsidiary of Apricus Biosciences.〔(【引用サイトリンク】title=Patent )
== Mechanism of action ==
DDAIP is a permeation enhancer that temporarily changes the permeation dynamics of the lipid bilayer and opens up the tight junctions between skin cells so active drug molecules can be rapidly absorbed through the skin into systemic circulation. It can also improve the solubility of compounds resulting in enhanced drug permeation.

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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