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Copeptin
Copeptin (also known as CT-proAVP) is a 39-amino acid-long peptide derived from a pre-pro-hormone consisting of vasopressin, and copeptin.
Arginine vasopressin (AVP), also known as the antidiuretic hormone (ADH), is involved in multiple cardiovascular and renal pathways and functions.
However, vasopressin measurements are not commonly used in clinical practice because of the biochemical features of the molecule: its small size and very short half-life make vasopressin testing quite complicated and labor-intensive. On the other hand, copeptin can be immunologically tested with ease and therefore be used as a vasopressin surrogate.
== Synthesis and secretion ==
Copeptin is a 39-amino acid-long, glycosylated peptide. It is synthesized mainly in the paraventricular neurons of the hypothalamus and in the supraoptical nucleus. During axonal transport, pre-pro-AVP is proteolytically cleaved into vasopressin, and copeptin. These molecules are then stored in secretory granules in the posterior pituitary and released upon osmotic or non-osmotic (hemodynamical; stress-related) stimuli.〔
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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