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Ceftolozane
Ceftolozane (Zerbaxa) is a 5th generation cephalosporin antibiotic, developed for the treatment of infections with gram-negative bacteria that have become resistant to conventional antibiotics. It was trialled for urinary tract infections, intra-abdominal infections and ventilator-associated bacterial pneumonia. Ceftolozane is combined with the β-lactamase inhibitor tazobactam, which protects ceftolozane from degradation.
Ceftolozane is indicated for the treatment of complicated urinary tract infections and complicated intra abdominal infections.〔http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm427534.htm〕
==Spectrum of Activity==
The in vitro activity of ceftolozane-tazobactam has been examined in five surveillance studies of isolates from Europe and North America. In these studies, Ceftolozane-tazobactam was notable for its activity against ''Pseudomonas aeruginosa'', a moderately common cause of hospital-acquired infections that is commonly multi-drug resistant. Ninety percent of ''Pseudomonas aeruginosa'' isolates were inhibited by a ceftolozane-tazobactam at a concentration of 4 μg/mL (MIC90, making it the most potent anti-pseudomonal antibiotic in clinical use.
In these same studies, ceftolozane-tazobactam exhibited MIC90 values of <1 μg/mL for ''Escherichia coli'', ''Citrobacter koseri'', ''Morganella morganii'', ''Proteus mirabilis'', ''Salmonella'' species, and ''Serratia marcescens''. Somewhat poorer activity is observed for the ''Klebsiella'' and ''Enterobacter'' species, with the MIC90 for extended spectrum beta lactamase (ESBL) expressing ''Klebsiella pnueumonia'' being >32μg/mL.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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