|
Cytochrome P450 4A11 is a protein that in humans is encoded by the ''CYP4A11'' gene.〔(【引用サイトリンク】 url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1579 )〕 == Function == This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and hydroxylates medium-chain fatty acids such as laurate and myristate.〔 CYP4A11 along with CYP4A22, CYP4F2, and CYP4F3 also metabolize arachidonic acid to 20-Hydroxyeicosatetraenoic acid (20-HETE) by an Omega oxidation reaction with the predominant 20-HETE-synthesizing enzymes in humans being CYP4F2 followed by CYP4A11; 20-HETE regulates blood flow, vascularization, blood pressure, and kidney tubule absorption of ions in rodents and possibly humans. Gene polymorphism variants of CYP4A11 are associated with the development of hypertension and cerebral infarction (i.e. ischemic stroke) in humans (see 20-Hydroxyeicosatetraenoic acid).〔Circulation. 2005 Jan 4;111(1):63-9〕〔J Am Soc Nephrol. 2008 Aug;19(8):1606-12. doi: 10.1681/ASN.2008010063〕〔J Hypertens. 2008 Mar;26(3):453-61. doi: 10.1097/HJH.0b013e3282f2f10c〕〔Hypertension. 2005 Oct;46(4):766-71〕〔Hypertension. 2008 Dec;52(6):1142-8. doi: 10.1161/HYPERTENSIONAHA.108.114082〕〔Pharmacogenet Genomics. 2010 Mar;20(3):187-94. doi: 10.1097/FPC.0b013e328336eefe〕 Members of the CYP4A and CYP4F sub-families and CYPU21 may also ω-hydroxylate and thereby reduce the activity of various fatty acid metabolites of arachidonic acid including LTB4, 5-HETE, 5-oxo-eicosatetraenoic acid, 12-HETE, and several prostaglandins that are involved in regulating various inflammatory, vascular, and other responses in animals and humans.〔Arch Biochem Biophys. 1998 Jul 15;355(2):201〕〔Biochem Pharmacol. 2008 Jun 15;75(12):2263-75. doi: 10.1016/j.bcp.2008.03.004〕 This hydroxylation-induced inactivation may underlie the proposed roles of the cytochromes in dampening inflammatory responses and the reported associations of certain CYP4F2 and CYP4F3 single nucleotide variants with human Krohn's disease and Coeliac disease, respectively.〔Eur J Hum Genet. 2006 Nov;14(11):1215-22〕〔Drug Metabol Drug Interact. 2012 Apr 19;27(2):63-71. doi: 10.1515/dmdi-2011-0037〕〔Gastroenterology. 2014 Apr;146(4):929-31. doi: 10.1053/j.gastro.2013.12.034〕 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「CYP4A11」の詳細全文を読む スポンサード リンク
|