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・ Ctenuchidia butus
・ Ctenuchidia fulvibasis
・ Ctenuchidia gundlachia
・ Ctenuchidia interrupta
・ Ctenuchidia subcyanea
・ Ctenuchidia virginalis
・ Ctenuchidia virgo
・ Ctenuchina
・ Ctenurella
・ Ctenus vespertilio
・ Ctenusa
・ Ctenusa curvilinea
・ Ctenusa pallida
・ Ctenusa varians
・ Ctenypena
CTEP
・ CTERA Networks
・ Ctesias
・ Ctesias (beetle)
・ Ctesias serra
・ Ctesibius
・ Ctesibius (crater)
・ Ctesicles
・ Ctesiphon
・ Ctesiphon (disambiguation)
・ Ctesiphon (orator)
・ Ctesiphon of Vergium
・ Ctesippus
・ Ctesylla
・ CTF


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CTEP : ウィキペディア英語版
CTEP

CTEP is a research drug developed by Hoffmann-La Roche that acts as a selective allosteric antagonist of the metabotropic glutamate receptor subtype mGluR5, binding with nanomolar affinity and over 1000x selectivity over all other receptor targets tested. In animal studies it was found to have a high oral bioavailability and a long duration of action, lasting 18 hours after a single dose, giving it considerably improved properties over older mGluR5 antagonists such as MPEP and fenobam.〔Lindemann L, Jaeschke G, Michalon A, Vieira E, Honer M, Spooren W, Porter R, Hartung T, Kolczewski S, Büttelmann B, Flament C, Diener C, Fischer C, Gatti S, Prinssen EP, Parrott N, Hoffmann G, Wettstein JG. CTEP: a novel, potent, long-acting, and orally bioavailable metabotropic glutamate receptor 5 inhibitor. ''Journal of Pharmacology and Experimental Therapeutics''. 2011 Nov;339(2):474-86. PMID 21849627〕
==References==



抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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