翻訳と辞書 Words near each other ・ Cox's Bazar Sadar Upazila ・ Cox's Cave ・ Cox's Cove ・ Cox's Criminal Cases ・ Cox's Orange Pippin ・ Cox's Ridge ・ Cox's Road ・ Cox's roundleaf bat ・ Cox's sandpiper ・ Cox's theorem ・ Cox's timepiece ・ Cox, Alicante ・ Cox, Florida ・ Cox, Haute-Garonne ・ COX-2 inhibitor ・ COX-3 ・ Cox-Ange House ・ Cox-Craddock House ・ Cox-Forbes theory ・ Cox-Hord House ・ COX-inhibiting nitric oxide donator ・ Cox-Klemin Aircraft Corporation ・ Cox-Klemin TW-2 ・ Cox-Klemin XA-1 ・ Cox-Klemin XS ・ Cox-Morton House ・ Cox-Parks House ・ Cox-Uithoven House ・ COX10 ・ COX15 Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク COX-3 ： ウィキペディア英語版 COX-3 COX-3 is an enzyme that is encoded by the ''PTGS1'' (''COX1'') gene, but is not functional in humans. COX-3 is the third and most recently discovered cyclooxygenase (COX) isozyme, the others being COX-1 and COX-2. The COX-3 isozyme is encoded by the same gene as COX-1, with the difference that COX-3 retains an intron that is not retained in COX-1. The other two cyclooxygenase isozymes are known to convert Dihomo-gamma-linolenic acid and Arachidonic acid into prostaglandins, and are the targets of nonsteroidal anti-inflammatory drugs (NSAIDs). == Transcription== COX-3 is transcribed from the ''PTGS1'' (''COX1'') gene, but the resulting mRNA is spliced differently. In dogs the resulting protein resembles the other two COX enzymes, but in mice and humans it does not, owing to a frame-shift mechanism. This mechanism is due to the fact that the spliced intron has 93 bases in dogs, resulting in the loss of 93:3 = 31 amino acids in the COX-3 sequence, which apparently does not impair its functionality. In humans, the intron is 94 bases long, leading to a protein with a completely different amino acid sequence from those of COX-1 or COX-2. The expressed protein does not show COX activity, and it is unlikely to play a role in prostaglandin-mediated physiological responses. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「COX-3」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.