翻訳と辞書
Words near each other
・ Bcl-2-associated X protein
・ Bcl-2-interacting killer
・ BCL-6 corepressor
・ Bcl-x interacting domain
・ Bcl-xL
・ BCL10
・ BCL11A
・ BCL11B
・ BCL2-like 1 (gene)
・ BCL2-related protein A1
・ BCL2L10
・ BCL2L11
・ BCL2L12
・ BCL2L13
・ BCL2L14
BCL2L2
・ BCL3
・ BCL6
・ BCL6B
・ BCL9
・ BCLAF1
・ BCLUW Community School District
・ BCM
・ BCM Classification
・ BCM Gravelines
・ BCM theory
・ BCMA
・ BCMaterials
・ BCMP
・ BCMP network


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BCL2L2 : ウィキペディア英語版
BCL2L2

Bcl-2-like protein 2 is a protein that in humans is encoded by the ''BCL2L2'' gene.〔(【引用サイトリンク】 url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=599 )〕 It was originally discovered by Leonie Gibson, Suzanne Cory and colleagues at the Walter and Eliza Hall Institute of Medical Research, who called it Bcl-w.''.
== Function ==

This gene encodes a pro-survival (anti-apoptotic) member of the bcl-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators. Expression of this gene in cells has been shown to contribute to reduced cell apoptosis under cytotoxic conditions. Studies of the related gene in mice indicated a role in the survival of NGF- and BDNF-dependent neurons. Mutation and knockout studies of the mouse gene demonstrated an essential role in adult spermatogenesis.〔
Relative to its Bcl-2 counterparts there is considerably less data on this particular protein. Located on chromosome 14q11 it appears to be redundant in most tissues apart from specific examples.

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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