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Azimilide
Azimilide is a class ΙΙΙ antiarrhythmic drug (used to control abnormal heart rhythms). The agents from this heterogeneous group have an effect on the repolarization, they prolong the duration of the action potential and the refractory period. Also they slow down the spontaneous discharge frequency of automatic pacemakers by depressing the slope of diastolic depolarization. They shift the threshold towards zero or hyperpolarize the membrane potential. Although each agent has its own properties and will have thus a different function.
== Heart potential ==
Azimilide dihydrochloride is a chlorophenylfuranyl compound, which slows repolarization of the heart and prolongs the QT interval of the electrocardiogram. Prolongation of atrial or ventricular repolarization can provide an anti-arrhythmic benefit in patients with heart rhythm disturbances, and this has been the primary interest in the clinical development azimilide. In rare cases, excessive prolongation of ventricular repolarization by azimilide can result in predisposition towards severe ventricular arrhythmias. Most recent clinical trials have investigated the use of azimilide in reducing the frequency and severity of arrhythmias in patients with implanted cardiac pacemakers-defibrillators, where rare pro-arrhythmic events are rescued by the device.
Image:Heartpotential.jpg|
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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