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|Section2= |Section3= }} Amentoflavone is a biflavonoid (''bis''-apigenin coupled at 8 and 3' positions, or 3′,8′′-Biapigenin) constituent of a number of plants including ''Ginkgo biloba'', ''Chamaecyparis obtusa'' (hinoki), ''Hypericum perforatum'' (St. John’s Wort) and ''Xerophyta plicata''. Amentoflavone can interact with many medications by being a potent inhibitor of CYP3A4 and CYP2C9, which are enzymes responsible for the metabolism of some drugs in the body. It is also an inhibitor of human cathepsin B.〔 Amentoflavone has a variety of ''in vitro'' activities including antimalarial activity, anticancer activity (which may, at least in part, be mediated by its inhibition of fatty acid synthase), and antagonist activity at the κ-opioid receptor (Ke = 490 nM)〔 〕 as well as activity at the allosteric benzodiazepine site of the GABAA receptor as a negative allosteric modulator. ==See also== * Apigenin 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Amentoflavone」の詳細全文を読む スポンサード リンク
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