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ABCC4
ATP-binding cassette sub-family C member 4 (ABCC4), also known as the multidrug resistance-associated protein 4 (MRP4) or multi-specific organic anion transporter B (MOAT-B), is a protein that in humans is encoded by the ''ABCC4'' gene.〔(【引用サイトリンク】 url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10257 )〕
ABCC4 acts as a regulator of intracellular cyclic nucleotide levels and as a mediator of cAMP-dependent signal transduction to the nucleus. MRP4/ABCC4 also transports prostaglandins, for example PGE2, out of the cell where they can bind receptors.〔Reid G, Wielinga P, Zelcer N,van der Heijden I, Kuil A, de Haas M, et al. The human multidrug resistanceprotein MRP4 functions as a prostaglandin efflux transporter and is inhibitedby nonsteroidal antiinflammatory drugs" ''Proc Natl Acad Sci U S A''2003;100(16) 9244-9.〕
MRP4/ABCC4 expression is dysregulated in several cancers 〔Ho LL, Kench JG, Handelsman DJ,Scheffer GL, Stricker PD, Grygiel JG, et al. Androgen regulation of multidrugresistance-associated protein 4 (MRP4/ABCC4) in prostate cancer" ''Prostate''2008;68(13) 1421-9.〕〔Copsel S, Garcia C, Diez F,Vermeulem M, Baldi A, Bianciotti LG, et al. Multidrug resistance protein 4(MRP4/ABCC4) regulates cAMP cellular levels and controls human leukemia cellproliferation and differentiation" ''J Biol Chem'' 2011;286(9) 6979-88.〕〔Holla VR, Backlund MG, Yang P,Newman RA, DuBois RN. Regulation of prostaglandin transporters in colorectalneoplasia. Cancer Prev Res (Phila). 2008;1(2) 93-9.〕 and is also upregulated in peritoneal endometriosis.〔Gori I, Rodriguez Y, Pellegrini C, Achtari C, Hornung D, Chardonnens E, Wunder D, Fiche M, CannyGO. Augmented epithelial multidrug resistance-associated protein 4 expression in peritoneal endometriosis: regulation by lipoxin A(4)" ''Fertil Steril'' 2013 Jun;99(7) 1965-73.e2. 〕
== Interactive pathway map ==
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