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・ Ababkov
・ Ababkovo
・ Abablar
・ Abablemma
・ Abablemma brimleyana
・ Ab Zalu-ye Sofla-ye Neqareh Khaneh
・ Ab Zalu-ye Vosta-ye Neqareh Khaneh
・ Ab Zaminu
・ Ab Zangi
・ Ab Zani
・ Ab Zardu
・ Ab Zehlu
・ Ab Zehlu, Andika
・ AB'S
・ AB(O)H antigens secretion
AB-001
・ AB-005
・ AB-0200
・ AB-25-class patrol craft
・ AB-3
・ AB-CHFUPYCA
・ AB-CHMFUPPYCA
・ AB-CHMINACA
・ Ab-e Barik-e Qowdi
・ Ab-e Gandu
・ Ab-e Garm Rural District
・ Ab-e Garm, Chaldoran
・ Ab-e Garm, East Azerbaijan
・ Ab-e Garm, Ganjabad
・ Ab-e Garm, Kazerun


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AB-001 : ウィキペディア英語版
AB-001

AB-001 or 1-pentyl-3-(1-adamantoyl)indole is a designer drug that was found as an ingredient in synthetic cannabis smoking blends in Ireland in 2010 and Hungary and Germany in 2011.〔(Research on Head Shop drugs in Dublin: Part 2 )〕 It is unclear who AB-001 was originally developed by, but it is structurally related to compounds such as AM-1248 and its corresponding 1-(tetrahydropyran-4-ylmethyl) analogue, which are known to be potent cannabinoid agonists with moderate to high selectivity for CB2 over CB1.〔
〕 The first published synthesis and pharmacological evaluation of AB-001 revealed that it acts as a full agonist at CB1 (EC50 = 35 nM) and CB2 receptors (EC50 = 48 nM). However, AB-001 was found to possess only weak cannabimimetic effects in rats at doses up to 30 mg/kg, making it less potent than the carboxamide analogue APICA, which possesses potent cannabimimetic activity at doses of 3 mg/kg.
==See also==

* A-834,735
* AB-005
* AM-1248
* APICA
* JWH-018
* JWH-250
* RCS-4
* RCS-8
* N-(S)-Fenchyl-1-(2-morpholinoethyl)-7-methoxyindole-3-carboxamide
* (1-Pentylindol-3-yl)-(2,2,3,3-tetramethylcyclopropyl)methanone

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
ウィキペディアで「AB-001」の詳細全文を読む



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