翻訳と辞書 Words near each other ・ 40 West 4th Centre ・ 40 Winks ・ 40 y Tantos ・ 40 Years ・ 40 Years – Then Death ・ 40 år i folkparkens tjänst ・ 40 år med Christer Sjögren ・ 40,000 Headmen ・ 4-nitrophenylphosphatase ・ 4-Nitropyridine-N-oxide ・ 4-Nitroquinoline 1-oxide ・ 4-Nitrotoluene ・ 4-Nonanoylmorpholine ・ 4-Nonylphenylboronic acid ・ 4-O-beta-D-mannosyl-D-glucose phosphorylase ・ 4-O-Methylhonokiol ・ 4-oxalmesaconate hydratase ・ 4-oxalocrotonate decarboxylase ・ 4-Oxalocrotonate tautomerase ・ 4-oxalomesaconate tautomerase ・ 4-Oxo-2-nonenal ・ 4-oxoproline reductase ・ 4-Phenyl-1,2,4-triazole-3,5-dione ・ 4-Phenyl-4-(1-piperidinyl)cyclohexanol ・ 4-Phenylazepane ・ 4-Phenylfentanyl ・ 4-Phenylpiperidine ・ 4-Phenylthiosemicarbazide ・ 4-phosphoerythronate dehydrogenase ・ 4-phosphopantoate—beta-alanine ligase Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク 4-O-Methylhonokiol ： ウィキペディア英語版 4-O-Methylhonokiol 4-''O''-Methylhonokiol is a neolignan, a type of phenolic compounds. It is found in the bark of ''Magnolia grandiflora'' and in ''M. virginiana'' flowers. 4-''O''-Methylhonokiol is a potent CB2 receptor ligand (Ki = 50 nM), showing a unique inverse agonism and partial agonism via different pathways (cAMP and Ca2+) and potently inhibits osteoclastogenesis. 4-O-Methylhonokiol further attenuates memory impairment in presenilin 2 mutant mice through reduction of oxidative damage and inactivation of astrocytes and the ERK pathway. The different neuroprotective and anti-Alzheimer Disease effects reported in rodent models may be mediated via CB2 receptors, providing that the compound should be orally bioavailable to the brain. It was shown that 4-''O''-methylhonokiol activates CB2 receptors and also inhibits the oxygenation of the major endocannabinoid 2-AG via COX-2 in a substrate-selective manner, thus leading to potential synergistic effects at CB receptors. The same study also provided data that this natural product can readily pass the blood–brain barrier, using LC-MS/MS. == References == 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「4-O-Methylhonokiol」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.