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|Section2= |Section3= }} 3-MCPD (3-monochloropropane-1,2-diol or 3-chloropropane-1,2-diol) is an organic chemical compound which is carcinogenic and highly suspected to be genotoxic in humans, has male anti-fertility effects, and is a chemical byproduct which may be formed in foods, the most commonly found member of chemical contaminants known as chloropropanols. It is primarily created in foods by protein hydrolysis by adding hydrochloric acid at high temperature to speed up the breakdown of proteins into amino acids. Under these conditions, chloride can react with the glycerol backbone of lipids to produce 3-MCPD. Another method 3-MCPD can also occur in foods which have been in contact with materials containing epichlorohydrin-based wet-strength resins - used in the production of some tea bags and sausage casings.〔(IFST issues statement on 3-MCPD )〕 It has been found in some East Asian and Southeast Asian sauces such as oyster sauce, Hoisin sauce and soy sauce.〔http://www.food.gov.uk/multimedia/webpage/soyproductsqa/〕 Using hydrochloric acid rather than traditional slow fermentation is a far cheaper and faster method but unavoidably creates chloropranols. An EFSA report indicated margarine, vegetable oils (excluding walnut oil), preserved meats, breads, and fine bakery wares as major sources in Europe.〔(Analysis of occurrence of 3-monochloropropane-1,2-diol (3-MCPD) in food in Europe in the years 2009-2011 and preliminary exposure assessment )〕 ==Absorption and toxicity== 3-MCPD is carcinogenic in rodents via a non-genotoxic mechanism. It is able to cross the blood-testis barrier and blood–brain barrier.〔Edwards et al. 1975〕 The oral of 3-chloro-1,2-propanediol is 152 mg/kg bodyweight in rats.〔Ericsson & Baker, 1970〕 3-MCPD also has male antifertility effects and can be used as a rat chemosterilant. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「3-MCPD」の詳細全文を読む スポンサード リンク
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