翻訳と辞書 Words near each other ・ Nicotiana sylvestris ・ Nicotiana tabacum ・ Nicotiana tomentosiformis ・ Nicotiana × sanderae ・ Nicotianamine ・ Nicotianamine aminotransferase ・ Nicotianamine synthase ・ Nicotianoideae ・ Nicotina ・ Nicotinamidase ・ Nicotinamide ・ Nicotinamide adenine dinucleotide ・ Nicotinamide adenine dinucleotide (phosphate) transhydrogenase ・ Nicotinamide adenine dinucleotide phosphate ・ Nicotinamide cofactor analogues ・ Nicotinamide N-methyltransferase ・ Nicotinamide nucleotide transhydrogenase ・ Nicotinamide phosphoribosyltransferase ・ Nicotinamide riboside ・ Nicotinamide-nucleotide adenylyltransferase ・ Nicotinamide-nucleotide amidase ・ Nicotinate dehydrogenase ・ Nicotinate dehydrogenase (cytochrome) ・ Nicotinate glucosyltransferase ・ Nicotinate hydroxylase ・ Nicotinate N-methyltransferase ・ Nicotinate phosphoribosyltransferase ・ Nicotinate riboside kinase ・ Nicotinate-nucleotide adenylyltransferase ・ Nicotinate-nucleotide diphosphorylase (carboxylating) Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Nicotinamide N-methyltransferase ： ウィキペディア英語版 Nicotinamide N-methyltransferase In enzymology, a nicotinamide N-methyltransferase (NNMT) () is an enzyme that catalyzes the chemical reaction : S-adenosyl-L-methionine + nicotinamide $\backslash rightleftharpoons$ S-adenosyl-L-homocysteine + 1-methylnicotinamide. Thus, the two substrates of this enzyme are S-adenosyl methionine and nicotinamide, whereas its two products are S-adenosylhomocysteine and 1-methylnicotinamide. This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:nicotinamide N-methyltransferase. This enzyme is also called nicotinamide methyltransferase. == Function == This enzyme participates in nicotinate and nicotinamide metabolism. NNMT affects a biochemical mechanism known as a futile cycle, which plays a role in metabolic regulation. NNMT is found in human fat cells and the liver. NNMT processes vitamin B3 and has been linked with certain types of cancer. Silencing the gene that codes for NNMT reduces its presence and increases the presence of sugar transporter GLUT4.〔 Mice that produced large amounts of GLUT4 were insulin sensitive and protected against diabetes, while mice with no GLUT4 were insulin resistant and at risk. High levels of NNMT are often found in the fat cells of animals that are insulin resistant. When the researchers silenced the NNMT gene in mice on high-fat diets, the mice gained less weight than those in whom the NNMT gene was functioning normally. (The mice did not change their eating or exercise habits).〔 Antisense oligonucleotide (ASO) technology can be used to silence the expression of the NNMT gene only in fat and liver cells. ASOs are short strings of DNA that can be designed to prevent the synthesis of specific proteins. ASOs have been approved for use by the U.S. Food and Drug Administration for the treatment of conditions with other genetic causes—such as elevated cholesterol and hyperlipidemia. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Nicotinamide N-methyltransferase」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.