|
Muscle spindles are sensory receptors within the belly of a muscle that primarily detect changes in the length of this muscle. They convey length information to the central nervous system via sensory neurons. This information can be processed by the brain to determine the position of body parts. The responses of muscle spindles to changes in length also play an important role in regulating the contraction of muscles, by activating motor neurons via the stretch reflex to resist muscle stretch. ] Muscle spindles are found within the belly of muscles, embedded in extrafusal muscle fibers. Note that "fusus" is the Latin word for spindle. Muscle spindles are composed of 3-12 intrafusal muscle fibers, of which there are three types: * dynamic nuclear bag fibers (bag1 fibers) * static nuclear bag fibers (bag2 fibers) * nuclear chain fibers and the axons of sensory neurons. Axons of gamma motoneurons also terminate in muscle spindles; they make synapses at either or both of the ends of the intrafusal muscle fibers and regulate the sensitivity of the sensory afferents, which are located in the non-contractile central (equatorial) region. Muscle spindles are encapsulated by connective tissue, and are aligned parallel to extrafusal muscle fibers, unlike Golgi tendon organs, which are oriented in series. The muscle spindle has both sensory and motor components. * Primary and secondary sensory nerve fibers spiral around and terminate on the central portions of the intrafusal muscle fibers, providing the sensory component of the structure via stretch-sensitive ion-channels of the axons. * In mammals including humans, the motor component is provided by up to a dozen gamma motoneurons and to a lesser extent by one or two beta motoneurons. Gamma and beta motoneurons are called fusimotor neurons, because they activate the intrafusal muscle fibers. Gamma motoneurons innervate only intrafusal muscle fibers, whereas beta motoneurons innervate both extrafusal and intrafusal muscle fibers and so are referred to as skeletofusimotor neurons. *Fusimotor drive causes a contraction and stiffening of the end portions of the intrafusal muscle fibers. Fusimotor neurons are classified as static or dynamic according to the type of intrafusal muscle fibers they innervate and their physiological effects on the responses of the Ia and II sensory neurons innervating the central, non-contractile part of the muscle spindle. * The static axons innervate the chain or bag2 fibers. They increase the firing rate of Ia and II afferents at a given muscle length (see schematic of fusimotor action below). * The dynamic axons innervate the bag1 intrafusal muscle fibers. They increase the stretch-sensitivity of the Ia afferents by stiffening the bag1 intrafusal fibers. ==Sensitivity modification== The function of the gamma motoneurons is not to supplement the force of muscle contraction provided by the extrafusal fibers, but to modify the sensitivity of the muscle spindle sensory afferents to stretch. Upon release of acetylcholine by the active gamma motoneuron, the end portions of the intrafusal muscle fibers contract, thus elongating the non-contractile central portions (see "fusimotor action" schematic below). This opens stretch-sensitive ion channels of the sensory endings, leading to an influx of sodium ions. This raises the resting potential of the endings, thereby increasing the probability of action potential firing, thus increasing the stretch-sensitivity of the muscle spindle afferents. For an interactive animation created by Jan Kowalczewski at the University of Alberta, demonstrating spindle afferent responses to muscle stretch with and without gamma (fusimotor) action, go to: (Arthur Prochazka's Lab, University of Alberta ) How does the central nervous system control gamma fusimotor neurons? It has been difficult to record from gamma motoneurons during normal movement because they have very small axons. Several theories have been proposed, based on recordings from spindle afferents. *1) ''Alpha-gamma coactivation.'' Here it is posited that gamma motoneurons are activated in parallel with alpha motoneurons to maintain the firing of spindle afferents when the extrafusal muscles shorten. *2) ''Fusimotor set:'' Gamma motoneurons are activated according to the novelty or difficulty of a task. Whereas static gamma motoneurons are continuously active during routine movements such as locomotion, dynamic gamma motoneoruns tend to be activated more during difficult tasks, increasing Ia stretch-sensitivity. *3) ''Fusimotor template of intended movement.'' Static gamma activity is a "temporal template" of the expected shortening and lengthening of the receptor-bearing muscle. Dynamic gamma activity turns on and off abruptly, sensitizing spindle afferents to the onset of muscle lengthening and departures from the intended movement trajectory. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Muscle spindle」の詳細全文を読む スポンサード リンク
|